Only in Tribeca would you get a comment about VC-backed companies in your graffiti. C. sent the photo above with this note: “I am so tired of bitchy people broadcasting their aggressive bitterness to the rest of us.”

The graffiti’s inspiration: Framebridge has taken the ground-floor space at 141 West Broadway between Duane and Thomas, replacing the local architect Audrey Matlock. (Her office has moved to 100 Church.) The longtime owner of the building — the son of the original owners of the Towers Cafeteria, who leased the space to The Odeon in 1980 — sold, and the new landlord needed to balance the budget.

More on that sentiment: A pal recently complained to me about recent comments berating the explosion of Pilates studios, most recently the one coming to Hudson and Beach. Her thought: welcome, and thank you for coming to our neighborhood and taking a chance on a small business here.

I get it. I would rather have a bank at Warren and Greenwich than an empty Gee Whiz. And I think Framebridge is a great tenant if you live on that block, knowing that a lot of them shared their displeasure when they thought Anotheroom was moving in. (And we know how folks freaked out when Anotheroom toggled to Washington and Vestry. They got what they asked for and the longtime Tribeca bar was replaced by a store for men’s luxury workout clothes.)

But I also understand the lament of losing independent businesses. That factored into my chat recently with the owners of Greenwich St. Jewelers on the occasion of their 50th (!) anniversary.

“It’s interesting to think about what Downtown was like back then,” Jennifer Gandia said — she owns the store her parents founded in Fidi with her sister, Christina Gandia Gambale. “It was predominantly mom and pop stores — small shops, independently owned. It was a real fabric of community, of people who made up the neighborhood.

“That’s one of those things that Tribeca really has maintained so beautifully that most neighborhoods have lost. Maybe I still see that because I look for it. It’s hard for any neighborhood to maintain that these days because of systemically what’s happening with the economy. But here I see Balloon Saloon and Korin and Fernandez and even the new ones – like Words on Warren. The stores look different than they did 50 years ago, but they are still people who want a neighborhood where they can establish an anchor.”

As for 141 West Broadway, I refuse to play the blame-the-landlord game: this was a building that was originally purchased decades ago — probably in the 1950s. It was sold by someone who inherited it and who does not live here and does not want to be a landlord. And it was bought by someone on the market who now has a mortgage to pay — the building was not a gift.

I don’t have a sweeping conclusion here. It’s just that the graffiti triggered what I see is a valid debate — and one that I am not sure has a definite winner in these crazy times.